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KMID : 0379519990150030307
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한국독성학회지
1999 Volume.15 No. 3 p.307 ~ p.312
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Cytokine Induction by a Polysaccharide-protein Complex Isolated from Agaricus blazei Murill
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Ku Hyun-Ok
Kim In-Cheon
Sim Young-Hwa
Jeong Sang-Hee
Kweon Chang-Hee
Park Shin-Ja
Kim Yun-Bae
Yoo Han-Sang
Lee Yong-Soon
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Abstract
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A polysaccharide-protein (74.1 : 12.8%) complex was extracted from Agaricus blazei Murill, and its cytokine-inducing potency was investigated in vitro and in vivo. In peritoneal macrophage cultures, the polysaccharide-protein complex induced a high level of interleukin-1α and interleukin-6 production in a dose-dependent manner. In contrast, tumor necrosis factor-α was not detected in the culture supernatant of macrophages stimulated with the polysaccharide-protein complex. Such an increased production of interleukin-6 was also observed in splenocyte cultures, while interleukin-2, interleukin-4, tumor necrosis factor-α and inteljeron-y were not significantly increased following stimulation. Such a pattern in cytokine induction by polysaccharide-protein complex was observed in mice, though it was transient 1-2 hr after intraperitoneal challenge. High levels (5,000-7,500 pg/ml) of interleukin-6 were achieved 1 hr after administration of 5-20 mg/kg of stimulus. Serum interleukin-1α, tumor necrosis factor-α and interferon-y levels were also increased to some extent, while interleukin-2 and interleukin-4 were not responsive. Taken together, it is suggested that interleukin-6 is the most responsive cytokine to stimulation with polysaccharide-protein complex from Agaricus blazei Murill.
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KEYWORD
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Polysaccharide-protein complex, Cytokine induction, Agaricus blazei Murill
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